Nphs1^tm1.1Tbh
Targeted Allele Detail

Summary

• Symbol: Nphs1^tm1.1Tbh
• Name: nephrosis 1, nephrin; targeted mutation 1.1, Tobias B Huber
• MGI ID: MGI:6356793
• Gene: Nphs1 Location: Chr7:30157740-30186648 bp, + strand Genetic Position: Chr7, 18.36 cM, cytoband A3
• Alliance: Nphs1^tm1.1Tbh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241326
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Three loxP sites were inserted into the gene, one in the 5-UTR of exon 1B, one in the 5-UTR of Exon 1A and the third flanking the PGK-neo selection cassette downstream of exon 5. Cre-mediated recombination resulted in deletion of the loxP flanked sequences. (J:241326)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nphs1 Mutation: 70 strains or lines available

References

• Original: J:241326 Grahammer F, et al., A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight. 2016 Jun 16;1(9)
• All: 1 reference(s)