Trim65^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim65^em1Cya
• Name: tripartite motif-containing 65; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6356825
• Synonyms: c.82-85del, strain 1, Trim65^-, Trim65^em1Cgen
• Gene: Trim65 Location: Chr11:116012672-116021954 bp, - strand Genetic Position: Chr11, 80.91 cM
• Alliance: Trim65^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN mutagenesis induced a 4 bp deletion in exon 1 (c.82-85del). The predicted length of the mutant protein is 63 amino acids. (J:240099)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim65 Mutation: 30 strains or lines available

References

• Original: J:240099 Lang X, et al., TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. J Exp Med. 2017 Feb;214(2):459-473
• All: 1 reference(s)