Trim65^em3Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim65^em3Cya
• Name: tripartite motif-containing 65; endonuclease-mediated mutation 3, Cyagen Biosciences
• MGI ID: MGI:6356827
• Synonyms: c.307del, strain 3, Trim65^-, Trim65^em3Cgen
• Gene: Trim65 Location: Chr11:116012672-116021954 bp, - strand Genetic Position: Chr11, 80.91 cM
• Alliance: Trim65^em3Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN mutagenesis induced a 1bp deletion in exon 1 (c.307del). The predicted length of the mutant protein is 142 amino acids. (J:240099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim65 Mutation: 30 strains or lines available

References

• Original: J:240099 Lang X, et al., TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. J Exp Med. 2017 Feb;214(2):459-473
• All: 1 reference(s)