Pnliprp1^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Pnliprp1^tm1Smoc
• Name: pancreatic lipase related protein 1; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6356882
• Synonyms: PLRP1^-
• Gene: Pnliprp1 Location: Chr19:58717319-58732601 bp, + strand Genetic Position: Chr19, 54.49 cM
• Alliance: Pnliprp1^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278344
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-8 were replaced by a neomycin selection cassette. RT-PCR and Western blot analysis confirmed the absence of transcripts and encoded protein in the pancreas of adult homozygous mutant mice. (J:278344)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pnliprp1 Mutation: 31 strains or lines available

References

• Original: J:278344 Ren J, et al., Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1. J Nutr Biochem. 2011 Jul;22(7):691-8
• All: 1 reference(s)