Prss55^tm1Zgwg
Targeted Allele Detail

Summary

• Symbol: Prss55^tm1Zgwg
• Name: serine protease 55; targeted mutation 1, Zhugang Wang
• MGI ID: MGI:6357155
• Synonyms: Prss55^-
• Gene: Prss55 Location: Chr14:64312887-64327611 bp, - strand Genetic Position: Chr14, 33.35 cM
• Alliance: Prss55^tm1Zgwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278420
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a PGK-neomycin selection cassette. The absence of the encoded protein expression was confirmed at both RNA and protein levels by semi-quantitative RT-PCR, Western blotting and IF analysis. (J:278420)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss55 Mutation: 19 strains or lines available

References

• Original: J:278420 Shang X, et al., Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding. Cell Mol Life Sci. 2018 Dec;75(23):4371-4384
• All: 1 reference(s)