Ddx46^em1Caox
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ddx46^em1Caox
• Name: DEAD box helicase 46; endonuclease-mediated mutation 1, Xuetao Cao
• MGI ID: MGI:6357907
• Synonyms: Ddx46^-
• Gene: Ddx46 Location: Chr13:55782841-55829069 bp, + strand Genetic Position: Chr13, 30.06 cM, cytoband B2
• Alliance: Ddx46^em1Caox page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was deleted by TALEN genome editing technology. Immunoblot analysis revealed a significant reduction of protein expression in macrophages from heterozygous mutant mice. (J:271836)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddx46 Mutation: 46 strains or lines available

References

• Original: J:271836 Zheng Q, et al., The RNA helicase DDX46 inhibits innate immunity by entrapping m(6)A-demethylated antiviral transcripts in the nucleus. Nat Immunol. 2017 Oct;18(10):1094-1103
• All: 1 reference(s)