Set^tm1.1Wgu
Targeted Allele Detail

Summary

• Symbol: Set^tm1.1Wgu
• Name: SET nuclear oncogene; targeted mutation 1.1, Wei Gu
• MGI ID: MGI:6357923
• Gene: Set Location: Chr2:29952074-29962589 bp, + strand Genetic Position: Chr2, 21.09 cM
• Alliance: Set^tm1.1Wgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276962
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression in homozygous embryos. (J:238814)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Set Mutation: 48 strains or lines available

References

• Original: J:238814 Wang D, et al., Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 06;538(7623):118-122
• All: 2 reference(s)