Angpt4^{tm1.1(cre)Ekl}
Targeted Allele Detail

Summary

• Symbol: Angpt4^{tm1.1(cre)Ekl}
• Name: angiopoietin 4; targeted mutation 1.1, Lauri Eklund
• MGI ID: MGI:6357966
• Gene: Angpt4 Location: Chr2:151753130-151787257 bp, + strand Genetic Position: Chr2, 74.83 cM
• Alliance: Angpt4^{tm1.1(cre)Ekl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267502
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Angpt4^{tm1.1(cre)Ekl} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Angpt4 (MGI:1336887)

• Mutation details: Using recombineering approach, targeting vector contained 1.2 and 11.4 kb genomic arms and Cre-pA-Frt-Neo-pA-Frt cassette inserted into the first exon of the Angpt4 gene was used in homologous recombination in ES cells. An Frt-flanked Neo cassette was removed by crossing with the ACTB-FLPe transgenic mouse line. (J:267502)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Angpt4 (mouse) Summary of all recombinase alleles driven by Angpt4. Comparative matrix view of recombinase activities Alliance mouse Angpt4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angpt4 Mutation: 30 strains or lines available

References

• Original: J:267502 Elamaa H, et al., Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina. Elife. 2018 Nov 16;7:e37776
• All: 2 reference(s)