Pick1^tm1.1Rlh
Targeted Allele Detail

Summary

• Symbol: Pick1^tm1.1Rlh
• Name: protein interacting with C kinase 1; targeted mutation 1.1, Richard L Huganir
• MGI ID: MGI:6358099
• Synonyms: Pick1^loxP
• Gene: Pick1 Location: Chr15:79113373-79133666 bp, + strand Genetic Position: Chr15, 37.7 cM, cytoband E2
• Alliance: Pick1^tm1.1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99813
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette with one loxP site was inserted into intron 3, and a second loxP site was introduced into intron 2. In addition, a FRT-flanked neomycin cassette was inserted. Flp-mediated recombination removed the FRT-flanked neo cassette. Deletion of exon 3 via Cre-mediated recombination will result in a frame-shift mutation. (J:99813)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pick1 Mutation: 22 strains or lines available

References

• Original: J:99813 Gardner SM, et al., Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron. 2005 Mar 24;45(6):903-15
• All: 3 reference(s)