Snx8^tm1Hbsh
Targeted Allele Detail

Summary

• Symbol: Snx8^tm1Hbsh
• Name: sorting nexin 8; targeted mutation 1, H-B Shu
• MGI ID: MGI:6358176
• Synonyms: Snx8^-
• Gene: Snx8 Location: Chr5:140326054-140375017 bp, - strand Genetic Position: Chr5, 78.95 cM
• Alliance: Snx8^tm1Hbsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254306
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Ten nucleotides were deleted in the second exon. Immunoblot analysis confirmed absence of protein expression in mouse embryonic fibroblasts and lung fibroblasts derived from homozygous mutant mice. (J:254306)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snx8 Mutation: 49 strains or lines available

References

• Original: J:254306 Wei J, et al., SNX8 mediates IFNgamma-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13000-13005
• All: 1 reference(s)