Mta3^{tm3d(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Mta3^{tm3d(KOMP)Wtsi}
• Name: metastasis associated 3; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:6358192
• Gene: Mta3 Location: Chr17:84013592-84128945 bp, + strand Genetic Position: Chr17, 54.53 cM, cytoband E4
• Alliance: Mta3^{tm3d(KOMP)Wtsi} page
• IMPC: Mta3 gene page

Mutation origin

• Mutant Cell Line: EPD0011_3_B08
• Germline Transmission: Earliest citation of germline transmission: J:278486
• Parent Cell Line: SI6.C21 (ES Cell)
• Strain of Origin: C57BL/6JCrl
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 84045266 of Chromosome 17 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 4 at position 84046183. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression resulted in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:278486)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mta3 Mutation: 121 strains or lines available

References

• Original: J:278486 Burgold T, et al., The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment. EMBO J. 2019 Jun 17;38(12)
• All: 1 reference(s)