Uqcrq^tm1.1Ncdl
Targeted Allele Detail

Summary

• Symbol: Uqcrq^tm1.1Ncdl
• Name: ubiquinol-cytochrome c reductase, complex III subunit VII; targeted mutation 1.1, Navdeep Chandel
• MGI ID: MGI:6358198
• Synonyms: QPC^fl
• Gene: Uqcrq Location: Chr11:53318749-53321658 bp, - strand Genetic Position: Chr11, 31.94 cM
• Alliance: Uqcrq^tm1.1Ncdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270630
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 1, and a FRT-flanked neomycin resistance (neo) cassette followed by a single loxP site downstream of exon 1 of the gene. Flp mediated recombination removed the neomycin cassette. (J:270630)

Expression

In Mice Carrying this Mutation:

186 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Uqcrq Mutation: 13 strains or lines available

References

• Original: J:270630 Weinberg SE, et al., Mitochondrial complex III is essential for suppressive function of regulatory T cells. Nature. 2019 Jan;565(7740):495-499
• All: 6 reference(s)