Mir31^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir31^em1Nju
• Name: microRNA 31; endonuclease-mediated mutation 1, Model Animal Research Center for Nanjing University
• MGI ID: MGI:6358205
• Gene: Mir31 Location: Chr4:88828794-88828899 bp, - strand Genetic Position: Chr4, 42.05 cM
• Alliance: Mir31^em1Nju page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted a 402 bp DNA fragment containing Mir31. (J:271420)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir31 Mutation: 5 strains or lines available

References

• Original: J:271420 Lv C, et al., MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nat Commun. 2017 Oct 19;8(1):1036
• All: 3 reference(s)