Mir31^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Mir31^tm1.1Smoc
• Name: microRNA 31; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:6358206
• Synonyms: miR-31^fl
• Gene: Mir31 Location: Chr4:88828794-88828899 bp, - strand Genetic Position: Chr4, 42.05 cM
• Alliance: Mir31^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271420
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The first exon (14,806-15,522) was flanked by loxP sites and an FRT-flanked neomycin selection cassette was inserted upstream of the loxP-flanked exon. Flp-mediated recombination removed the neomycin leaving the floxed exon. (J:271420)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir31 Mutation: 5 strains or lines available

References

• Original: J:271420 Lv C, et al., MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nat Commun. 2017 Oct 19;8(1):1036
• All: 4 reference(s)