AW112010^em2Flv
Endonuclease-mediated Allele Detail

Summary

• Symbol: AW112010^em2Flv
• Name: expressed sequence AW112010; endonuclease-mediated mutation 2, Richard A Flavell
• MGI ID: MGI:6358209
• Synonyms: Aw112010^Stop
• Gene: AW112010 Location: Chr19:11024976-11027930 bp, - strand Genetic Position: Chr19, 7.59 cM
• Alliance: AW112010^em2Flv page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: A small 14-nucleotide sequence (TAATTAATTAATTA) was targeted into the second exon of the Aw112010 gene using CRISPR/Cas9. This sequence contains a stop codon in all three frames and will also frameshift any protein-coding sequene upon insertion. (J:267975)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any AW112010 Mutation: 6 strains or lines available

References

• Original: J:267975 Jackson R, et al., The translation of non-canonical open reading frames controls mucosal immunity. Nature. 2018 Dec;564(7736):434-438
• All: 1 reference(s)