Sema6d^tm1.1Jiao
Targeted Allele Detail

Summary

• Symbol: Sema6d^tm1.1Jiao
• Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; targeted mutation 1.1, Kai Jiao
• MGI ID: MGI:6358299
• Synonyms: Sema6D^loxP
• Gene: Sema6d Location: Chr2:123931889-124509690 bp, + strand Genetic Position: Chr2, 60.69 cM
• Alliance: Sema6d^tm1.1Jiao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254695
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 4-7 were flanked by loxP sites and a FRT-flanked PGK-neo cassette was inserted immediately downstream of the second loxP site. Flp-mediated recombination removed the PGK-neo cassette leaving exons 4-7 floxed. (J:254695)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema6d Mutation: 62 strains or lines available

References

• Original: J:254695 Peng Y, et al., Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice. Cardiovasc Res. 2016 Nov 1;112(2):532-542
• All: 2 reference(s)