Chia1^tm1.1Lof
Targeted Allele Detail

Summary

• Symbol: Chia1^tm1.1Lof
• Name: chitinase, acidic 1; targeted mutation 1.1, Lori J Fitz
• MGI ID: MGI:6358337
• Synonyms: AMCase^-
• Gene: Chia1 Location: Chr3:106020698-106039434 bp, + strand Genetic Position: Chr3, 46.49 cM, cytoband F3
• Alliance: Chia1^tm1.1Lof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257728
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 4 and a neomycin resistance gene cassette and a second loxP site into intron 5. Exon 5 (and the neo cassette) was deleted through subsequent cre-mediated recombination. (J:257728)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chia1 Mutation: 53 strains or lines available

References

• Original: J:257728 Fitz LJ, et al., Acidic mammalian chitinase is not a critical target for allergic airway disease. Am J Respir Cell Mol Biol. 2012 Jan;46(1):71-9
• All: 4 reference(s)