Psd2^em1Sakag
Endonuclease-mediated Allele Detail

Summary

• Symbol: Psd2^em1Sakag
• Name: pleckstrin and Sec7 domain containing 2; endonuclease-mediated mutation 1, Hiroyuki Sakagami
• MGI ID: MGI:6358601
• Gene: Psd2 Location: Chr18:36097883-36147768 bp, + strand Genetic Position: Chr18, 19.34 cM
• Alliance: Psd2^em1Sakag page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated recombination deleted 112 nucleotides in exon 1. Immunoblot analysis of cerebellar lysates from homozygous mice confirmed the absence of full length wild-type protein. (J:275832)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psd2 Mutation: 35 strains or lines available

References

• Original: J:275832 Saegusa S, et al., Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions. PLoS One. 2019;14(5):e0216960
• All: 1 reference(s)