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Psd2em1Sakag
Endonuclease-mediated Allele Detail
Summary
Symbol: Psd2em1Sakag
Name: pleckstrin and Sec7 domain containing 2; endonuclease-mediated mutation 1, Hiroyuki Sakagami
MGI ID: MGI:6358601
Gene: Psd2  Location: Chr18:36097883-36147768 bp, + strand  Genetic Position: Chr18, 19.34 cM
Alliance: Psd2em1Sakag page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 mediated recombination deleted 112 nucleotides in exon 1. Immunoblot analysis of cerebellar lysates from homozygous mice confirmed the absence of full length wild-type protein. (J:275832)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psd2 Mutation:  35 strains or lines available
References
Original:  J:275832 Saegusa S, et al., Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions. PLoS One. 2019;14(5):e0216960
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory