Golga2^tm1.1Baos
Targeted Allele Detail

Summary

• Symbol: Golga2^tm1.1Baos
• Name: golgin A2; targeted mutation 1.1, Shilai Bao
• MGI ID: MGI:6358612
• Synonyms: GM130^fl, GM130^flox
• Gene: Golga2 Location: Chr2:32178299-32197925 bp, + strand Genetic Position: Chr2, 22.09 cM
• Alliance: Golga2^tm1.1Baos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 14 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 14 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:272184)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Golga2 Mutation: 53 strains or lines available

References

• Original: J:272184 Liu C, et al., Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):346-351
• All: 4 reference(s)