Nin^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Nin^{tm1c(EUCOMM)Hmgu}
• Name: ninein; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6358683
• Synonyms: ninein Fl
• Gene: Nin Location: Chr12:70058209-70160491 bp, - strand Genetic Position: Chr12, 28.94 cM, cytoband C3
• Alliance: Nin^{tm1c(EUCOMM)Hmgu} page
• IMPC: Nin gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277726
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Flp-mediated excision of the parental Nin^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the lacZ and neomycin selection cassette leaving exon 2 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:277726)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nin Mutation: 82 strains or lines available

References

• Original: J:277726 Lecland N, et al., Epidermal development requires ninein for spindle orientation and cortical microtubule organization. Life Sci Alliance. 2019 Apr;2(2)
• All: 1 reference(s)