Nin^{tm1d(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Nin^{tm1d(EUCOMM)Hmgu}
• Name: ninein; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6358684
• Gene: Nin Location: Chr12:70058209-70160491 bp, - strand Genetic Position: Chr12, 28.94 cM, cytoband C3
• Alliance: Nin^{tm1d(EUCOMM)Hmgu} page
• IMPC: Nin gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277726
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated excision of the Nin^{tm1c(EUCOMM)Hmgu} allele resulted in the deletion of exon 2. Immunoblotting and immunostaining analysis confirmed absence of protein in embryonic fibroblasts and skin sections, respectively. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:277726)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nin Mutation: 82 strains or lines available

References

• Original: J:277726 Lecland N, et al., Epidermal development requires ninein for spindle orientation and cortical microtubule organization. Life Sci Alliance. 2019 Apr;2(2)
• All: 1 reference(s)