Cpne5^tm1Mfan
Targeted Allele Detail

Summary

• Symbol: Cpne5^tm1Mfan
• Name: copine V; targeted mutation 1, Ming Fan
• MGI ID: MGI:6358726
• Gene: Cpne5 Location: Chr17:29375495-29456764 bp, - strand Genetic Position: Chr17, 15.14 cM
• Alliance: Cpne5^tm1Mfan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274122
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first exon and about 2.6 kb of upstream sequence (containing the start code) were replaced with a PGK-Neo-cassette via homologous recombination. Immunohistochemical staining confirmed the absence of protein expression in the hippocampus of adult homozygous mutant mice. (J:274122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpne5 Mutation: 50 strains or lines available

References

• Original: J:274122 Ding XF, et al., Cpne5 is Involved in Regulating Rodent Anxiety Level. CNS Neurosci Ther. 2017 Mar;23(3):266-268
• All: 1 reference(s)