Rufy1^em1Lagbu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rufy1^em1Lagbu
• Name: RUN and FYVE domain containing 1; endonuclease-mediated mutation 1, Camron Bryant
• MGI ID: MGI:6358745
• Synonyms: Rufy1^-
• Gene: Rufy1 Location: Chr11:50280113-50321952 bp, - strand Genetic Position: Chr11, 30.57 cM
• Alliance: Rufy1^em1Lagbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232145
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Left TAL effector (50,244,600-50,244,616 bp) and right TAL effector (50,244,569-50,244,585 bp) separated by the FokI cleavage zone was used to introduce a frameshift deletion in the first coding exon (exon 1). The mutation results in a premature stop codon. Founder 3 was established. (J:232145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rufy1 Mutation: 35 strains or lines available

References

• Original: J:232145 Yazdani N, et al., Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity. PLoS Genet. 2015 Dec;11(12):e1005713
• All: 1 reference(s)