Sppl2c^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Sppl2c^{tm1.1(KOMP)Vlcg}
• Name: signal peptide peptidase 2C; targeted mutation 1.1, Velocigene
• MGI ID: MGI:6358787
• Gene: Sppl2c Location: Chr11:104077153-104081989 bp, + strand Genetic Position: Chr11, 67.79 cM
• Alliance: Sppl2c^{tm1.1(KOMP)Vlcg} page
• IMPC: Sppl2c gene page

Mutation origin

• Mutant Cell Line: 12958A-E7
• Germline Transmission: Earliest citation of germline transmission: J:272982
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 4464bp between positions 104047693-104052156 of Chromosome 11 (Genome Build37). The floxed neo resistance gene that is part if the cassette was removed via Cre mediated recombination. (J:272982)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sppl2c Mutation: 35 strains or lines available

References

• Original: J:272982 Niemeyer J, et al., The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Rep. 2019 Mar;20(3)
• All: 3 reference(s)