Adam3^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Adam3^tm1Osb
• Name: ADAM metallopeptidase domain 3; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6358812
• Synonyms: Adam3^{tm1a(KOMP)Osb}
• Gene: Adam3 Location: Chr8:25167241-25215868 bp, - strand Genetic Position: Chr8, 13.09 cM, cytoband A2
• Alliance: Adam3^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266476
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using targeting vector DPGS00107_A_C12, an IRES:lacZ trapping cassette and a floxed promoter-driven neomycin cassette replaced exons 12-16. (J:266476)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam3 Mutation: 61 strains or lines available

References

• Original: J:266476 Fujihara Y, et al., Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice. J Cell Sci. 2018 Oct 8;131(19):jcs221481
• All: 3 reference(s)