Dbh^{tm1.1(flpo)Pjen}
Targeted Allele Detail

Summary

• Symbol: Dbh^{tm1.1(flpo)Pjen}
• Name: dopamine beta hydroxylase; targeted mutation 1.1, Patricia Jensen
• MGI ID: MGI:6358815
• Synonyms: Dbh^Flpo
• Gene: Dbh Location: Chr2:27055519-27073216 bp, + strand Genetic Position: Chr2, 19.29 cM
• Alliance: Dbh^{tm1.1(flpo)Pjen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Dbh^{tm1.1(flpo)Pjen} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dbh (MGI:94864)

• Mutation details: A targeting vector containing a Flpo-poly(A) cassette and a loxP-flanked PGK/Em7-Neo cassette was used to replace 107 bp of exon 1 of the gene. Cre-mediated recombination removed the floxed neo cassette. (J:198264)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dbh (mouse) Summary of all recombinase alleles driven by Dbh. Alliance mouse Dbh gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dbh Mutation: 17 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Dbh^{tm1(flpo)Pjen}, has been analyzed.

References

• Original: J:198264 Robertson SD, et al., Developmental origins of central norepinephrine neuron diversity. Nat Neurosci. 2013 Aug;16(8):1016-23
• All: 5 reference(s)