Cmtm2b^em2Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cmtm2b^em2Osb
• Name: CKLF-like MARVEL transmembrane domain containing 2B; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6359391
• Synonyms: Cmtm2b⁺⁴⁴⁴
• Gene: Cmtm2b Location: Chr8:105048862-105057396 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cmtm2b^em2Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• CRISPR-targeting of exon 1 produced a 313 bp deletion and a 757 bp insertion. (J:266476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cmtm2b Mutation: 10 strains or lines available

References

• Original: J:266476 Fujihara Y, et al., Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice. J Cell Sci. 2018 Oct 8;131(19):jcs221481
• All: 2 reference(s)