Zc3h12ctm2d(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Zc3h12ctm2d(EUCOMM)Hmgu |
Name: |
zinc finger CCCH type containing 12C; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:6359732 |
Gene: |
Zc3h12c Location: Chr9:52022644-52079872 bp, - strand Genetic Position: Chr9, 28.62 cM
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Alliance: |
Zc3h12ctm2d(EUCOMM)Hmgu page
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IMPC: |
Zc3h12c gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:277714
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 52031228 of Chromosome 9 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 52032143. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression resulted in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:277714)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Zc3h12c Mutation: |
36 strains or lines available
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Original: |
J:277714 von Gamm M, et al., Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J Exp Med. 2019 Jul 1;216(7):1700-1723 |
All: |
1 reference(s) |
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