Oprl1^tm1.1Mrbr
Targeted Allele Detail

Summary

• Symbol: Oprl1^tm1.1Mrbr
• Name: opioid receptor-like 1; targeted mutation 1.1, Michael R Bruchas
• MGI ID: MGI:6359736
• Synonyms: NOPR^lox, NOPR^loxP/YFP
• Gene: Oprl1 Location: Chr2:181356809-181362778 bp, + strand Genetic Position: Chr2, 103.74 cM, cytoband H2-4
• Alliance: Oprl1^tm1.1Mrbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278343
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct is designed to contain a loxP site upstream of exon 3, an EYFP reporter fused to the 3' end of exon 4, a polyA, and an FRT flanked neomycin cassette followed by a second loxP site. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:278343)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprl1 Mutation: 28 strains or lines available

References

• Original: J:278343 Parker KE, et al., A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward. Cell. 2019 Jul 25;178(3):653-671.e19
• All: 1 reference(s)