Mirc53^tm1.1Gning
Targeted Allele Detail

Summary

• Symbol: Mirc53^tm1.1Gning
• Name: microRNA cluster 53, including Mir221 and Mir222; targeted mutation 1.1, Guang Ning
• MGI ID: MGI:6359860
• Gene: Mirc53 Location: unknown Genetic Position: ChrX, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278082
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT and loxP-flanked neomycin resistance cassette was inserted 500 bp downstream of Mir221. Another loxP site was inserted 3000 bp upstream Mir222. Flp-mediated recombination removed the selection cassette and left the two microRNA floxed. (J:278082)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc53 Mutation: 1 strain or line available

References

• Original: J:278082 Jiang X, et al., Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice. EBioMedicine. 2018 Nov;37:307-321
• All: 1 reference(s)