Gk2^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gk2^em1Osb
• Name: glycerol kinase 2; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6359868
• Synonyms: Gk2^-7
• Gene: Gk2 Location: Chr5:97603001-97604880 bp, - strand Genetic Position: Chr5, 47.71 cM
• Alliance: Gk2^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of the coding sequence deleted 7 bp resulting in a frameshift and premature termination. (J:278674)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gk2 Mutation: 20 strains or lines available

References

• Original: J:278674 Shimada K, et al., Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis. J Reprod Dev. 2019 Apr 12;65(2):155-162
• All: 1 reference(s)