Mir146^tm1.1Lfl
Targeted Allele Detail

Summary

• Symbol: Mir146^tm1.1Lfl
• Name: microRNA 146; targeted mutation 1.1, Li-Fan Lu
• MGI ID: MGI:6359885
• Synonyms: miR-146a^fl
• Gene: Mir146 Location: Chr11:43265224-43265288 bp, - strand Genetic Position: Chr11, 25.68 cM
• Alliance: Mir146^tm1.1Lfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266124
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a loxP site and a single loxP site flank the microRNA sequence. Flp-mediated recombination removed the selection cassette and left the microRNA sequence floxed. (J:266124)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir146 Mutation: 9 strains or lines available

References

• Original: J:266124 Cho S, et al., Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 2018 Jul 16;9(1):2757
• All: 3 reference(s)