Tefm^tm1.2Lrsn
Targeted Allele Detail

Summary

• Symbol: Tefm^tm1.2Lrsn
• Name: transcription elongation factor, mitochondrial; targeted mutation 1.2, Nils-Goran Larsson
• MGI ID: MGI:6360157
• Gene: Tefm Location: Chr11:80027504-80033001 bp, - strand Genetic Position: Chr11, 47.53 cM
• Alliance: Tefm^tm1.2Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276874
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked puromycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. (J:276874)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tefm Mutation: 52 strains or lines available

References

• Original: J:276874 Jiang S, et al., TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep. 2019 Jun;20(6)
• All: 1 reference(s)