Fank1^em1Mngx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fank1^em1Mngx
• Name: fibronectin type 3 and ankyrin repeat domains 1; endonuclease-mediated mutation 1, Mingxi Liu
• MGI ID: MGI:6360213
• Synonyms: Fank1^-
• Gene: Fank1 Location: Chr7:133378594-133483261 bp, + strand Genetic Position: Chr7, 77.42 cM
• Alliance: Fank1^em1Mngx page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated mutagenesis created a 70-bp deletion in exon 2. Western blot analysis confirmed the absence of protein expression in homozygous mutant testes. (J:278620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fank1 Mutation: 22 strains or lines available

References

• Original: J:278620 Zhang J, et al., Normal spermatogenesis in Fank1 (fibronectin type 3 and ankyrin repeat domains 1) mutant mice. PeerJ. 2019;7:e6827
• All: 1 reference(s)