Tiam2^tm1Bgh
Targeted Allele Detail

Summary

• Symbol: Tiam2^tm1Bgh
• Name: T cell lymphoma invasion and metastasis 2; targeted mutation 1, Bernhard G Herrmann
• MGI ID: MGI:6360470
• Synonyms: Tiam2^LS
• Gene: Tiam2 Location: Chr17:3376675-3569672 bp, + strand Genetic Position: Chr17, 1.99 cM, cytoband A1
• Alliance: Tiam2^tm1Bgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273736
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The selection cassette and triple polyadenylation sequence replaced part of exon 16 and exon 17 (chr. 17, bases 3,502,894 to 3,505,764, in GRCm38.p4). This allele expresses neither the long or short transcript. (J:273736)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tiam2 Mutation: 105 strains or lines available

References

• Original: J:273736 Charron Y, et al., Two isoforms of the RAC-specific guanine nucleotide exchange factor TIAM2 act oppositely on transmission ratio distortion by the mouse t-haplotype. PLoS Genet. 2019 Feb;15(2):e1007964
• All: 1 reference(s)