Fbln7^tm1.1Hiya
Targeted Allele Detail

Summary

• Symbol: Fbln7^tm1.1Hiya
• Name: fibulin 7; targeted mutation 1.1, Hiromi Yanagisawa
• MGI ID: MGI:6360596
• Synonyms: Fbln7^-, Fbln7^KO
• Gene: Fbln7 Location: Chr2:128705791-128738954 bp, + strand Genetic Position: Chr2, 62.63 cM, cytoband F3
• Alliance: Fbln7^tm1.1Hiya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271278
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is derived from Fbln7^tm1Hiya. Cre-mediated recombination resulted in the excision of the floxed sequence containing exon 2 and an FRT-flanked neo cassette. qPCR analysis revealed a severe loss of expression in the cortex and medulla of homozygous mutant kidneys. In situ hybridization confirmed the absence of expression in mutant kidney sections at the cortex level. (J:271278)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbln7 Mutation: 33 strains or lines available

References

• Original: J:271278 Tsunezumi J, et al., Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice. Matrix Biol. 2018 Dec;74:5-20
• All: 1 reference(s)