Tg(Amelx-icre)876Ppap
Transgene Detail

Summary

• Symbol: Tg(Amelx-icre)876Ppap
• Name: transgene insertion 876, Petros Papagerakis
• MGI ID: MGI:6360640
• Synonyms: Amelx-iCre(876)
• Transgene: Tg(Amelx-icre)876Ppap Location: unknown
• Alliance: Tg(Amelx-icre)876Ppap page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Amelx-icre)876Ppap expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Amelx (MGI:88005)

• Mutation details: The transgene was created by modifying BAC by replacing exon 2 of mouse Amelx gene with an improved cre recombinase gene (icre). An FRT-flanked kanomycin resistance cassette was removed prior to injection. 4 independent BAC founder lines (854, 863, 872, and 876) were collected. Line 876 showed the strongest X-gal staining in ameloblasts. However, non-specific staining in the osteoclasts and osteoblasts are noted. (J:278625)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Amelx (mouse) Summary of all recombinase alleles driven by Amelx. Comparative matrix view of recombinase activities Alliance mouse Amelx gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:278625 Said R, et al., Generation of Amelx-iCre Mice Supports Ameloblast-Specific Role for Stim1. J Dent Res. 2019 Aug;98(9):1002-1010
• All: 1 reference(s)