Atf3^{tm1.1(cre/ERT2)Msra}
Targeted Allele Detail

Summary

• Symbol: Atf3^{tm1.1(cre/ERT2)Msra}
• Name: activating transcription factor 3; targeted mutation 1.1, Matt S Ramer
• MGI ID: MGI:6360893
• Synonyms: ATF3-CreERT2
• Gene: Atf3 Location: Chr1:190902493-190915530 bp, - strand Genetic Position: Chr1, 96.28 cM, cytoband H6
• Alliance: Atf3^{tm1.1(cre/ERT2)Msra} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Atf3^{tm1.1(cre/ERT2)Msra} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Atf3 (MGI:109384)

• Mutation details: Thetargeting vector was constructed to insert a construct directly after the ATG start codon of the mouse Atf3 gene containing: Cre fused to the mutated estrogen-ligand binding domain (CreERT2), 1.2 kb of Atf3 3' untranslated region, a Simian virus 40 stop signal and a neomycin cassette flanked by two FLP recognition target sites. The neo cassette was removed from founders by crossing with Flp recombinase mice. It is a null allele. (J:278945)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atf3 (mouse) Summary of all recombinase alleles driven by Atf3. Comparative matrix view of recombinase activities Alliance mouse Atf3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf3 Mutation: 21 strains or lines available

References

• Original: J:278945 Denk F, et al., Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis. Acta Neuropathol Commun. 2015 Nov 26;3:74
• All: 3 reference(s)