Pogz^tm1.2Jrk
Targeted Allele Detail

Summary

• Symbol: Pogz^tm1.2Jrk
• Name: pogo transposable element with ZNF domain; targeted mutation 1.1, Jonathan R Keller
• MGI ID: MGI:6360952
• Gene: Pogz Location: Chr3:94744878-94789637 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Pogz^tm1.2Jrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271614
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 13. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 19. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 13 through 19 floxed. (J:271614)

Expression

In Mice Carrying this Mutation:	23 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pogz Mutation: 54 strains or lines available

References

• Original: J:271614 Gudmundsdottir B, et al., POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin and Human Fetal Hemoglobin Expression. Cell Rep. 2018 Jun 12;23(11):3236-3248
• All: 1 reference(s)