Elp6^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Elp6^em1(IMPC)J
• Name: elongator acetyltransferase complex subunit 6; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6361007
• Gene: Elp6 Location: Chr9:110134241-110151170 bp, + strand Genetic Position: Chr9, 59.91 cM
• Alliance: Elp6^em1(IMPC)J page
• IMPC: Elp6 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CTATGAGGAAGGCCTAGCCG and GCCATCCTCCCAGCAAATGA, which resulted in a 1813 bp deletion beginning at Chromosome 9 position 110,312,464 bp and ending after 110,314,276 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000220060 and ENSMUSE00000220064 (exons 3 and 4) and 1623 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 44 and early truncation 18 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Elp6 Mutation: 31 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)