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Nus1tm1.2Qrm
Targeted Allele Detail
Summary
Symbol: Nus1tm1.2Qrm
Name: NUS1 dehydrodolichyl diphosphate synthase subunit; targeted mutation 1.2, Qing Robert Miao
MGI ID: MGI:6361026
Synonyms: NgBRKO, Nus1ko
Gene: Nus1  Location: Chr10:52293643-52316279 bp, + strand  Genetic Position: Chr10, 26.64 cM
Alliance: Nus1tm1.2Qrm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229464
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a loxP site and FRT-flanked neo cassette were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination in the germline removed exons 2-4. (J:229464)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nus1 Mutation:  19 strains or lines available
References
Original:  J:229464 Rana U, et al., Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. Dev Biol. 2016 Feb 15;410(2):190-201
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory