Slc36a4^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc36a4^em1(IMPC)J
• Name: solute carrier family 36 (proton/amino acid symporter), member 4; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6361107
• Gene: Slc36a4 Location: Chr9:15621034-15653684 bp, + strand Genetic Position: Chr9, 5.12 cM
• Alliance: Slc36a4^em1(IMPC)J page
• IMPC: Slc36a4 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CACATCAGTTTTACCAGCAG and CCAAATGCTGTGTCCCTCAG, which resulted in a 365 bp deletion beginning at Chromosome 9 position 15,719,595 bp and ending after 15,719,959 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000341746 (exon 2) and 241 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 15 and early truncation 18 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slc36a4 Mutation: 32 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)