Cdkn1a^{em3(cre/ERT)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdkn1a^{em3(cre/ERT)Smoc}
• Name: cyclin dependent kinase inhibitor 1A; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
• MGI ID: MGI:6361244
• Synonyms: P21-CreER
• Gene: Cdkn1a Location: Chr17:29309953-29319696 bp, + strand Genetic Position: Chr17, 15.12 cM
• Alliance: Cdkn1a^{em3(cre/ERT)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Cdkn1a^{em3(cre/ERT)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cdkn1a (MGI:104556)

• Mutation details: A CreER cDNA was inserted into the stop codon of the gene. A linker encoding a 2A self-cleaving peptide sequence was inserted upstream of the cre/ERT construct to allow simultaneous expression of CreER and Cdkn1a. (J:278880)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdkn1a (mouse) Summary of all recombinase alleles driven by Cdkn1a. Comparative matrix view of recombinase activities Alliance mouse Cdkn1a gene page

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn1a Mutation: 63 strains or lines available

References

• Original: J:278880 Li Y, et al., Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth. Cell Res. 2018 Jul;28(7):775-778
• All: 1 reference(s)