Peak1^tm1.2Itl
Targeted Allele Detail

Summary

• Symbol: Peak1^tm1.2Itl
• Name: pseudopodium-enriched atypical kinase 1; targeted mutation 1.2, inGenious Targeting Laboratory
• MGI ID: MGI:6361447
• Gene: Peak1 Location: Chr9:56108410-56325351 bp, - strand Genetic Position: Chr9, 30.13 cM
• Alliance: Peak1^tm1.2Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278882
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 4. (J:278882)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Peak1 Mutation: 71 strains or lines available

References

• Original: J:278882 Wang H, et al., Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discov. 2018;4:26
• All: 1 reference(s)