Tek^em1(dre)Bzsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tek^em1(dre)Bzsh
• Name: TEK receptor tyrosine kinase; endonuclease-mediated mutation 1, Bin Zhou
• MGI ID: MGI:6361468
• Synonyms: Tie2-Dre
• Gene: Tek Location: Chr4:94627526-94763213 bp, + strand Genetic Position: Chr4, 43.34 cM
• Alliance: Tek^em1(dre)Bzsh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Tek^em1(dre)Bzsh expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tek (MGI:98664)

• Mutation details: The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. A cDNA encoding Dre recombinase, followed by a polyadenylation sequence, was inserted into the translation start site of the Tek gene. (J:236001)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

Expression

In Mice Carrying this Mutation:

80 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tek Mutation: 92 strains or lines available

References

• Original: J:236001 Zhang H, et al., Endocardium Contributes to Cardiac Fat. Circ Res. 2016 Jan 22;118(2):254-65
• All: 3 reference(s)