Gal^tm1.1Pjen
Targeted Allele Detail

Summary

• Symbol: Gal^tm1.1Pjen
• Name: galanin and GMAP prepropeptide; targeted mutation 1.1, Patricia Jensen
• MGI ID: MGI:6361662
• Synonyms: Gal^cKO
• Gene: Gal Location: Chr19:3459915-3464544 bp, - strand Genetic Position: Chr19, 3.16 cM
• Alliance: Gal^tm1.1Pjen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285301
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted downstream of exon 2. The cassette is composed of, from 5' to 3', an FRT site, a lacZ sequence, a loxP site, and neomycin sequence followed by a second FRT site and a second loxP site. A third loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette leaving exon 3 floxed. (J:285301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gal Mutation: 23 strains or lines available

References

• Original: J:285301 Tillage RP, et al., Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors. Brain Struct Funct. 2020;225(2):785-803
• All: 1 reference(s)