Slco3a1^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slco3a1^em1Smoc
• Name: solute carrier organic anion transporter family, member 3a1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6361972
• Gene: Slco3a1 Location: Chr7:73925167-74204528 bp, - strand Genetic Position: Chr7, 42.95 cM, cytoband D1
• Alliance: Slco3a1^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 127 base pair deletion in exon 2 resulting in a frameshift mutation. Western blot and immunofluorescent analysis confirmed absence of protein. (J:279167)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slco3a1 Mutation: 60 strains or lines available

References

• Original: J:279167 Pan Q, et al., Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology. 2018 Nov;155(5):1578-1592.e16
• All: 1 reference(s)