Smarcc2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Smarcc2^em1(IMPC)J
• Name: SWI/SNF related BAF chromatin remodeling complex subunit C2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6362053
• Gene: Smarcc2 Location: Chr10:128295117-128326351 bp, + strand Genetic Position: Chr10, 76.59 cM
• Alliance: Smarcc2^em1(IMPC)J page
• IMPC: Smarcc2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TTATTCTTTTGGACTAAGCG and AAATGTAATTCCTTAAAAGG, which resulted in a 435 bp deletion beginning at Chromosome 10 position 128,462,848 bp and ending after 128,463,282 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000150241 (exon 3) and 349 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 77 and early truncation 21 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Smarcc2 Mutation: 56 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)