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Rdh7tm1c(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Rdh7tm1c(KOMP)Wtsi
Name: retinol dehydrogenase 7; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6362645
Synonyms: Rdh7-floxed
Gene: Rdh7  Location: Chr10:127719897-127724686 bp, - strand  Genetic Position: Chr10, 76.39 cM, cytoband D3
Alliance: Rdh7tm1c(KOMP)Wtsi page
IMPC: Rdh7 gene page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:279231
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 127723095 of Chromosome 10 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 127723948. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:279231)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rdh7 Mutation:  23 strains or lines available
References
Original:  J:279231 Grizotte-Lake M, et al., Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis. Immunity. 2018 Dec 18;49(6):1103-1115.e6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory