Terb2^em2Leim
Endonuclease-mediated Allele Detail

Summary

• Symbol: Terb2^em2Leim
• Name: telomere repeat binding bouquet formation protein 2; endonuclease-mediated mutation 2, Ming Lei
• MGI ID: MGI:6362936
• Synonyms: Terb2^F188R
• Gene: Terb2 Location: Chr2:122016753-122036874 bp, + strand Genetic Position: Chr2, 60.56 cM, cytoband F1
• Alliance: Terb2^em2Leim page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting produced the amino acid substitution of arginine for phenylalanine at position 188 (F188R). (J:270644)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Terb2 Mutation: 10 strains or lines available

References

• Original: J:270644 Wang Y, et al., The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope. Nat Commun. 2019 Feb 4;10(1):564
• All: 1 reference(s)